Background The post-trial period is the time period after the end of study drug administration. It is unclear whether post-trial arrangements for patient surveillance are routinely included in study protocols and consents, and whether research ethics boards (REB) consider the post-trial period. Objectives The objective was to determine whether trial protocols and consent forms reviewed by the REB describe procedures for post-trial period surveillance. Methods An observational study of protocols of randomised trials of chronic therapies for cardiac conditions, approved by (...) the REB of two academic institutions affiliated with the University of Toronto in Canada (University Health Network and Mount Sinai Hospital) from 1995 to 2007. Plans for patient surveillance in the post-trial period described in the protocol or in the consent form before and after REB approval were recorded. Results 42 studies were identified including 18 heart failure and 15 coronary artery disease trials. Only four studies planned a clinical visit after trial termination, and an additional three planned a telephone contact after trial completion. Five trials submitted consent forms to the REB with a discussion of the post-trial period. Conclusions The majority of protocols and consent forms did not discuss plans for post-trial period surveillance. The post-trial period and the REB approval process could be improved by systematic follow-up being described in the protocol and consent form. The small number of trial protocols evaluated in the study may impair the degree to which the results can be generalised. (shrink)

kn. 1. Vechnye voprosy v svete nauki, filosofii religii.

Upshot: We agree with commenters that enactivism incorporates a broad variety of methodologies, metaphysical stances, concepts, and investigative approaches, and that this is a good thing. However, we remain concerned that autonomy and sense-making are problematic concepts for post-Varelian enactivism, and that they form the foundations of a conceptual framework that may hamper the development of effective explanations for cognitive activity, as well as the paradigmatic aspirations of this particular enactivist approach.

Ask various people what phenomenon in the social development of the capitalist countries in the 1960s was most astonishing, and the answer many would give would probably be: the mass protest of the younger generation.

This small book packs a considerable theoretical and practical punch. Alan Ware challenges much received wisdom about the dynamics of two party politics. In the process, he adds considerably to contemporary discussion of the intersection of structure and agency in the development and adaptation of political systems. Ware picks out two party systems for concentrated attention because of their relative tractability – in his words: ‘these systems are ideal for analysing the capacity of parties to pursue their interests in the (...) face of both other actors within the political system and also of elements within the party itself. (shrink)

Politics in Islam is not divorced from the system of beliefs in the supernatural, Islam is not an isolated factor, it forms an inseparable complex with political phenomena, which is very unusual for people raised within the Christian tradition, where the separation of politics and religion is common and desirable. With regard to the situation in Crimea, the most important manifestations of the interconnection between Islam and politics in the peninsula are the following: the Muslim component of the Majlis foreign (...) policy; the role of Islam in the Majlis nationalist project; Islam as a means of communication with foreign Islamic organizations; Arabic and Turkish vectors of influence; activities of radical Islamic organizations and groups. (shrink)